Development of an end-game strategy towards apoptolidin: a sequential Suzuki coupling approach

An end-game strategy towards the synthesis of apoptolidin has been demonstrated in a model study, in which the C(1)–C(15) fragment was successfully assembled using three consecutive Suzuki coupling reactions. Graphical Abstract

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Bibliographic Details
Published inTetrahedron Vol. 61; no. 2; pp. 401 - 408
Main Authors Jin, Bohan, Liu, Qingsong, Sulikowski, Gary A.
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier Ltd 10.01.2005
Elsevier
Subjects
Chemistry
Chemistry, Organic
Cross-coupling
Natural product synthesis
Physical Sciences
Science & Technology
Trienoate
Natural product synthesis
Trienoate
Cross-coupling
ANTITUMOR ANTIBIOTICS
ISOAPOPTOLIDIN
trienoate
ASYMMETRIC ALDOL ADDITIONS
natural product synthesis
ORGANOBORANES
APOPTOSIS INDUCER
MACROCYCLIC CORE
BIS(PINACOLATO)DIBORON
CONSTRUCTION
cross-coupling
FRAGMENT
TRANSFORMED-CELLS
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Summary:An end-game strategy towards the synthesis of apoptolidin has been demonstrated in a model study, in which the C(1)–C(15) fragment was successfully assembled using three consecutive Suzuki coupling reactions. Graphical Abstract
ISSN:0040-4020
1464-5416
DOI:10.1016/j.tet.2004.10.088