Combination of Calcium Hydroxylapatite Diluted With Normal Saline and Microfocused Ultrasound With Visualization for Skin Tightening

• Published in: Journal of drugs in dermatology Vol. 19; no. 4; p. 405
• Main Authors: Yutskovskaya, Yana Alexandrovna, Sergeeva, Anna Daniilovna, Kogan, Evgeniya Altarovna
• Format: Journal Article
• Language: English
• Published: United States 01.04.2020
• Subjects: Adult; Biocompatible Materials - administration & dosage; Biocompatible Materials - therapeutic use; Combined Modality Therapy; Durapatite - administration & dosage; Durapatite - therapeutic use; Facial Dermatoses - pathology; Facial Dermatoses - therapy; Female; Humans; Injections, Subcutaneous; Patient Satisfaction; Skin Aging; Treatment Outcome; Ultrasonic Therapy
• ISSN: 1545-9616
• DOI: 10.36849/JDD.2020.4625

Background/Objectives: Treatment options for the correction of age-related changes in skin include the use of energy-based devices and dermal fillers. In this study, we evaluate the clinical efficacy and tolerability of microfocused ultrasound with visualization (MFU-V) and injectable calcium hydroxylapatite (CaHA) filler diluted with normal saline, for the correction of age-related changes and to assess patients' satisfaction with this combination therapy. Methods: This was a randomized, split-face, comparative clinical study and immunohistochemical analysis in 20 subjects with indications for lower face, neck and décolleté lifting. Over five visits, CaHA diluted with normal saline (1:2) was injected subdermally in the lower third of the face, neck and décolleté, and lower abdominal quadrant. MFU-V was performed on the lower third of the face, neck, and décolleté, and the right lower abdominal quadrant. Results: Upon baseline examination, the age-related changes were quantified as follows: marionette lines score 2.47 ± 0.8, jawline contour score 2.2 ± 0.7 and neck score 2.1 ± 0.7 points; and after 15 months, they changed to 1.8 ± 0.7 (P≤0.00003), 1.89 ± 0.56 (P≤0.005), and 1.7 ± 0.6 (P≤0.005) points, respectively. The procedures were well tolerated, and subject satisfaction was high. Conclusions: The injections of CaHA in combination with MFU-V treatment stimulated neoangiogenesis, led to the increased synthetic activity of cells, a marked increase in collagen and elastin fibers, and remodeling of both the superficial and deep layers of the dermis. An improvement in the severity of age-related changes was observed in all areas studied. J Drugs Dermatol. 2020;19(4):405-411. doi:10.36849/JDD.2020.4625.