Sulfasalazine-Loaded Copper-Tannic Acid Coordination Nanozyme Enables ROS Scavenging and Immunomodulation for Inflammatory Bowel Disease Therapy

• Published in: Advanced healthcare materials p. e2403738
• Main Authors: Yan, Jian-Hua, Liang, Chun-Xiao, Ma, Ran-Ran, Li, Bo-Jia, Chen, Qi-Wen, Li, Wen, Zeng, Xuan, Zhang, Xian-Zheng
• Format: Journal Article
• Language: English
• Published: Germany 08.12.2024
• Subjects: immunomodulation; sulfasalazine; nanozyme; inflammatory bowel disease; ROS
• ISSN: 2192-2659
• DOI: 10.1002/adhm.202403738

Inflammatory bowel disease (IBD) is associated with elevated levels of reactive oxygen species (ROS) and an increased expression of proinflammatory cytokines. Anti-inflammatory drugs, monoclonal antibodies, and immunomodulators are commonly employed to control the inflammatory response in the management of IBD. Here, a copper and tannic acid (TA) coordination nanozyme (CuTA) loaded with sulfasalazine (SSZ-CuTA) is synthesized for the treatment of IBD by simultaneous scavenging ROS and immunosuppression. The CuTA exhibits both dismutase-like activity and catalase-like activity, making it efficient at scavenging ROS. These nanozymes can efficiently traverse gastric acid and subsequently exert their effects within the intestinal tract. It is verified that SSZ-CuTA can restore intestinal mucosal and goblet cells to a healthy state by effectively eliminating ROS and reducing the pro-inflammatory factors in a mouse IBD model. Overall, the SSZ-CuTA will offer a promising alternative treatment for patients suffering from IBD where excessive ROS and high inflammation coexist.