Exploration of the Human Microbiome’s Role in Health and Disease through the Lens of Genetics

• Published in: Journal of pure & applied microbiology : an international research journal of microbiology Vol. 18; no. 3; pp. 1413 - 1423
• Main Authors: Alanazi, Awadh, Younas, Sonia, Ejaz, Hasan, Mazhari, Bi Bi Zainab, Abosalif, Khalid, Abdalla, Abualgasim Elgaili, Alruwaili, Muharib, Atif, Muhammad, Junaid, Kashaf
• Format: Journal Article
• Language: English
• Published: Oriental Scientific Publishing Company 01.09.2024; Journal of Pure and Applied Microbiology
• Subjects: Anopheles; Disease susceptibility; Ecosystems; factors influencing microbiome; Gastrointestinal diseases; Gene expression; Genes; Genetic aspects; Genetics; Health aspects; healthy bacteria; host genetic background; host-microbiome interaction; Infection; microbiome variations; Microbiota (Symbiotic organisms); microbiota adaptation; Prevention; Skin; United Kingdom
• ISSN: 0973-7510; 2581-690X
• DOI: 10.22207/JPAM.18.3.61

The human microbiome is a complex ecosystem of bacteria residing in the body. It plays a crucial role in safeguarding the overall well-being of individuals while also making them more vulnerable to various diseases. The human microbiota, genetics, and health have a complex connection, which is significant for maintaining health and preventing infections. The microbiome has a role in several gastrointestinal, skin, dental, and systemic diseases, such as obesity, diabetes, and autoimmune disorders. Genetic variation and lifestyle and dietary choices modify the microbiome composition, thereby influencing the risk of developing severe infections. The microbiome impacts host gene expression and acts as a biomarker for several diseases. The gut microbiome and genes are linked in the pathogenesis of obesity and inflammatory bowel disease. Therefore, this review focuses on the relationship between the microbiome and genetics and elucidation of the complexity of this connection. Future research-based microbiome interventions to prevent diseases could lead to strategies for personalized medicine that enhance treatment efficacy and health outcomes.