Novel sesquiterpenoids as tyrosine kinase inhibitors produced by Stachybotrys chortarum

In the course of screening for small-molecule inhibitors to Tyrosine kinase receptor seven novel K-76 derivatives ( 1– 7 ) have been isolated from the fungal culture of Stachybotrys chortarum. The structures were elucidated by extensive mono- and bi- dimensional spectroscopy and mass spectrometry. G...

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Bibliographic Details
Published inTetrahedron Vol. 60; no. 10; pp. 2379 - 2385
Main Authors Vázquez, Marı́a J, Vega, Alfonso, Rivera-Sagredo, Alfonso, Jiménez-Alfaro, Marı́a D, Dı́ez, Emilio, Hueso-Rodrı́guez, Juan A
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier Ltd 01.03.2004
Elsevier
Subjects
Chemistry
Chemistry, Organic
K76
Physical Sciences
Science & Technology
Sesquiterpenoids
Stachybotrys chortarum
Tyrosine kinase receptor
K76
Tyrosine kinase receptor
Sesquiterpenoids
Stachybotrys chortarum
GROWTH
sesquiterpenoids
ANGIOGENESIS INHIBITOR
ARTHRITIS
tyrosine kinase receptor
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Summary:In the course of screening for small-molecule inhibitors to Tyrosine kinase receptor seven novel K-76 derivatives ( 1– 7 ) have been isolated from the fungal culture of Stachybotrys chortarum. The structures were elucidated by extensive mono- and bi- dimensional spectroscopy and mass spectrometry. Graphic
ISSN:0040-4020
1464-5416
DOI:10.1016/j.tet.2004.01.014