Multi-Encapsulation Combination of O/W/O Emulsions with Polyurea Microcapsules for Controlled Release and Safe Application of Dimethyl Disulfide

• Published in: ACS applied materials & interfaces Vol. 13; no. 1; pp. 1333 - 1344
• Main Authors: Ren, Lirui, Huang, Bin, Fang, Wensheng, Zhang, Daqi, Cheng, Hongyan, Song, Zhaoxin, Yan, Dongdong, Li, Yuan, Wang, Qiuxia, Zhou, Zhiqiang, Cao, Aocheng
• Format: Journal Article
• Language: English
• Published: United States 13.01.2021
• Subjects: Animals; Anti-Infective Agents - toxicity; Capsules - chemistry; Capsules - toxicity; Cucumis sativus - drug effects; Delayed-Action Preparations - chemistry; Delayed-Action Preparations - toxicity; Disulfides - toxicity; Drug Carriers - chemistry; Drug Carriers - toxicity; Drug Liberation; Emulsions - chemistry; Emulsions - toxicity; Fusarium - drug effects; Phytophthora - drug effects; Polymers - chemistry; Polymers - toxicity; Soil Microbiology; Tylenchoidea - drug effects; controlled release; multiple emulsions; dimethyl disulfide; polyurea microcapsules; safe application
• ISSN: 1944-8244; 1944-8252
• DOI: 10.1021/acsami.0c16613

Dimethyl disulfide (DMDS), a promising alternative fumigant, has been highly desirable for excellent management of soil pests and diseases. However, high volatility and moderate toxicity of this sulfide limit its application. To address these issues, a novel controlled release formulation of DMDS was proposed employing multiple emulsions and polyurea microcapsules (DMDS@MEs-MCs). The successful combination of the two technologies was revealed by confocal laser scanning microscopy, scanning electron microscopy, thermogravimetric analysis, and Fourier transform infrared. According to the multiple encapsulation structure, the encapsulation efficiency decreased by only 3.13% after thermal storage, compared with a 15.21% decrease of microcapsules made with only a monolayer film. DMDS@MEs-MCs could effectively control the release of active ingredient, which increased applicator and environmental safety during application. Moreover, it could be facilely used by spraying and drip irrigation instead of a special fumigation device. The innovative formulation exhibited better control efficacy on soil pathogens ( spp. and spp.) and root-knot nematodes ( spp.) than DMDS technical concentration (DMDS TC). In addition, it did not inhibit seed germination after 10 days when the plastic film was removed from the fumigated soil. This method appears to be of broad interest for the development of safe and handy fumigant application.