A case of Epstein–Barr virus-negative human immunodeficiency virus-related primary effusion lymphoma

• Published in: Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy Vol. 24; no. 6; pp. 487 - 491
• Main Authors: Ota, Shinichiro, Fujikura, Yuji, Yamamoto, Takayuki, Maki, Yohei, Kurokawa, Atsushi, Maeda, Takuya, Kanoh, Soichiro, Kawana, Akihiko
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 01.06.2018
• Subjects: Epstein–Barr virus (EBV); Human herpesvirus 8 (HHV-8); Human immunodeficiency virus (HIV); Positron emission tomography (PET); Primary effusion lymphoma (PEL); Positron emission tomography (PET); Human herpesvirus 8 (HHV-8); Primary effusion lymphoma (PEL); Epstein–Barr virus (EBV); Human immunodeficiency virus (HIV)
• ISSN: 1341-321X; 1437-7780
• DOI: 10.1016/j.jiac.2018.01.011

Primary effusion lymphoma (PEL) is a rare subtype of large B-cell lymphoma associated with human herpesvirus-8. Most cases are co-infected with Epstein–Barr virus (EBV). The prognosis of PEL is extremely poor and no optimal treatment regimen has been established. We report a case of EBV-negative PEL in a 49-year-old human immunodeficiency virus-positive man, presenting with massive bilateral pleural effusion.