An Adhesive and Corrosion-Resistant Biomarker Sensing Film for Biosmart Wearable Consumer Electronics

• Published in: Journal of microelectromechanical systems Vol. 29; no. 5; pp. 1112 - 1114
• Main Authors: Zhao, Yichao, Wang, Bo, Hojaiji, Hannaneh, Lin, Shuyu, Lin, Haisong, Zhu, Jialun, Yeung, Christopher, Emaminejad, Sam
• Format: Journal Article
• Language: English
• Published: New York IEEE 01.10.2020; The Institute of Electrical and Electronics Engineers, Inc. (IEEE)
• Subjects: Biomarkers; Biosensors; Biosmart consumer electronics; Chemical sensors; Circuits; Consumer electronics; Corrosion resistance; Corrosive wear; electrochemical sensing; Electronics; Galvanic corrosion; Glucose; Internet of Things; Metals; personalized and precision medicine; Position sensing; Reaction mechanisms; Sensors; Substrates; Sugar; sweat metabolites; Wearable sensors; wearable sweat analysis; Wearable technology
• ISSN: 1057-7157; 1941-0158
• DOI: 10.1109/JMEMS.2020.3012101

The integration of electrochemical sensors in wearable consumer electronics enables monitoring the health status of individuals at molecular levels across the general population, and thus can play a critical role in transforming personalized and precision medicine. Previously, we devised a seamless integration strategy to interface disposable mediator-free enzymatic sensors-constructed on anisotropic conductive films (ACFs)-with consumer electronics. To illustrate the generalizability of our approach, here, we leverage ACF electrodes as a foundation to develop widely used mediator-based enzymatic sensors, which possess different underlying reaction mechanisms. Accordingly, we demonstrated the ACF-based sensor's anti-corrosive performance and its compatibility for integration with contact pads on both flexible and rigid substrates. To position this mediator-based sensor for untreated biofluid analysis, we adopted a post-calibration methodology to facilitate sensor surface conditioning. To demonstrate the clinical utility of our approach, a representative mediator-based enzymatic glucose sensor was developed and coupled with contact pads on a circuit board to analyze the changes in sweat glucose levels with respect to meal intake (n = 26). The generalizability of the ACF-based sensor development and integration strategy allows for its adoption to target a wide panel of biomarkers and to transform the wearable consumer electronics into biosmart platforms. [2020-0193]