Determination of the Relationship Between the Development and Recurrence of Subacute Thyroiditis and Human Leukocyte Antigen Subtypes

• Published in: Genetic testing and molecular biomarkers Vol. 28; no. 1; p. 2
• Main Authors: Korkmaz, Fatma Nur, Gökçay Canpolat, Asena, Dalva, Klara, Elhan, Atilla Halil, Şahin, Mustafa, Çorapçıoğlu, Demet, Demir, Özgür
• Format: Journal Article
• Language: English
• Published: United States 01.01.2024
• Subjects: HLA Antigens - genetics; HLA-A Antigens; HLA-B Antigens - genetics; HLA-C Antigens - genetics; HLA-DRB1 Chains - genetics; Humans; Prospective Studies; Thyroiditis, Subacute - genetics; Autoimmunity; subacute thyroiditis; disease susceptibility; Human Leukocyte Antigens
• ISSN: 1945-0257
• DOI: 10.1089/gtmb.2023.0386

There are several studies investigating the role of human leukocyte antigens (HLA) in the development and recurrence of subacute thyroiditis (SAT). The HLA subtypes associated with SAT were usually determined in a population-based manner and , , , and were detected to play a role in the disease susceptibility and prognosis. The aim of this study was to determine HLA alleles associated with the tendency of recurrence and prevention of SAT within the Turkish population. This prospective study was conducted with 51 SAT patients and 720 healthy bone marrow donor volunteers. HLA-A, -B, -C, -DRB1, and -DQB1 were genotyped using next-generation sequencing. The frequency of , , , , were associated with an increased risk of SAT development (Odds Ratio: 22.4, 9.5, 10.3, 4.2, and 3.5, respectively). While , , , were associated with nonrelapsing SAT, was associated with relapsing SAT. , , and were more frequent both in relapsing and nonrelapsing groups according to control group. The frequency of , reported as a risk factor previously, was similar in the SAT and control groups (  = 0.959). was associated with a lower risk of SAT development. Along with - and , was detected as an important risk factor for SAT development in our population. appears to be the protective HLA subtype against SAT. , , , , , , and subtypes can establish a tendency to relapsing or nonrelapsing SAT.