The spectrum of multiple sclerosis

Multiple sclerosis (MS) is the most common cause of chronic neurologic disability in young people. Genetic susceptibility and unidentified environmental triggers appear to be necessary in order to result in disease. MS is an extraordinarily complex trait with evidence of heterogeneity at clinical, p...

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Bibliographic Details
Published inCurrent allergy and asthma reports Vol. 7; no. 4; pp. 280 - 284
Main Author Heard, Robert N S
Format Journal Article
LanguageEnglish
Published United States Springer Nature B.V 01.07.2007
Subjects
Adolescent
Adult
Age Factors
Child
Child, Preschool
Children & youth
Chronic Disease
Female
Humans
Male
Medical research
Multiple sclerosis
Multiple Sclerosis - etiology
Multiple Sclerosis - pathology
Multiple Sclerosis - physiopathology
Multiple Sclerosis - therapy
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Summary:Multiple sclerosis (MS) is the most common cause of chronic neurologic disability in young people. Genetic susceptibility and unidentified environmental triggers appear to be necessary in order to result in disease. MS is an extraordinarily complex trait with evidence of heterogeneity at clinical, pathologic, and therapeutic levels. Recent studies have not resolved the important question whether at a mechanistic level MS is a single disease with a wide spectrum of clinical expression, or whether it encompasses a group of separate diseases that share certain pathologic final common pathways. This question is important not only for helping to understand the causes of MS but also for designing and applying better treatments.
ISSN:1529-7322
1534-6315
DOI:10.1007/s11882-007-0042-y