Assessment of the effectiveness of ultraviolet-C disinfection on transmission of hospital-acquired pathogens from prior room occupants

• Published in: Antimicrobial stewardship & healthcare epidemiology : ASHE Vol. 2; no. 1; p. e110
• Main Authors: Hodges, Jacob C, Bilderback, Andrew L, Bridge, Christine M, Wagester, Suzanne, Colaianne, Bonnie V, Babiker, Ahmed, Minnier, Tami, Zapf, Rachel L, Kip, Paula L, Snyder, Graham M
• Format: Journal Article
• Language: English
• Published: England Cambridge University Press 2022
• Subjects: Original
• ISSN: 2732-494X; 2732-494X
• DOI: 10.1017/ash.2022.254

To evaluate the effectiveness of ultraviolet-C (UV-C) disinfection as an adjunct to standard chlorine-based disinfectant terminal room cleaning in reducing transmission of hospital-acquired multidrug-resistant organisms (MDROs) from a prior room occupant. A retrospective cohort study was conducted to compare rates of MDRO transmission by UV-C status from January 1, 2016, through December 31, 2018. Acute-care, single-patient hospital rooms at 6 hospitals within an academic healthcare system in Pennsylvania. Transmission of hospital-acquired MDRO infection was assessed in patients subsequently assigned to a single-patient room of a source occupant with carriage of 1 or more MDROs on or during admission. Acquisition of 5 pathogens was compared between exposed patients in rooms with standard-of-care chlorine-based disinfectant terminal cleaning with or without adjunct UV-C disinfection. Logistic regression analysis was used to estimate the adjusted risk of pathogen transfer with adjunctive use of UV-C disinfection. In total, 33,771 exposed patient admissions were evaluated; the source occupants carried 46,688 unique pathogens. Prior to the 33,771 patient admissions, 5,802 rooms (17.2%) were treated with adjunct UV-C disinfection. After adjustment for covariates, exposed patients in rooms treated with adjunct UV-C were at comparable risk of transfer of any pathogen (odds ratio, 1.06; 95% CI, 0.84-1.32; = .64). Our analysis does not support the use of UV-C in addition to post-discharge cleaning with chlorine-based disinfectant to lower the risk of prior room occupant pathogen transfer.