ω-3PUFAs prevent MK-801-induced cognitive impairment in schizophrenic rats via the CREB/BDNF/TrkB pathway

• Published in: Journal of Huazhong University of Science and Technology. Medical sciences Vol. 37; no. 4; pp. 491 - 495
• Main Authors: Fang, Mao-sheng, Li, Xing, Qian, Hong, Zeng, Kuan, Ye, Meng, Zhou, Yong-jie, Li, Hui, Wang, Xiao-chuan, Li, Yi
• Format: Journal Article
• Language: English
• Published: Wuhan Huazhong University of Science and Technology 01.08.2017; Department of Pathophysiology, School of Basic Medicine and the Collaborative Innovation Center for Brain Science, Key Laboratory of Ministry of Education of China for Neurological Disorders, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China%Department of Pathophysiology, School of Basic Medicine and the Collaborative Innovation Center for Brain Science, Key Laboratory of Ministry of Education of China for Neurological Disorders, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China; Wuhan Mental Health Center, Wuhan 430022, China%Department of Pathophysiology, School of Basic Medicine and the Collaborative Innovation Center for Brain Science, Key Laboratory of Ministry of Education of China for Neurological Disorders, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China%Wuhan Mental Health Center, Wuhan 430022, China; Co-innovation Center of Neuroregeneration, Nantong 226001, China
• Subjects: Animals; Brain-Derived Neurotrophic Factor - metabolism; Cell Count; Cognitive Dysfunction - chemically induced; Cognitive Dysfunction - complications; Cognitive Dysfunction - drug therapy; Cognitive Dysfunction - prevention & control; Cyclic AMP Response Element-Binding Protein - metabolism; Dizocilpine Maleate; Extracellular Signal-Regulated MAP Kinases - metabolism; Fatty Acids, Omega-3 - pharmacology; Fatty Acids, Omega-3 - therapeutic use; Hippocampus - pathology; Medicine; Medicine & Public Health; Neurons - drug effects; Neurons - metabolism; Neurons - pathology; Phosphorylation - drug effects; Proto-Oncogene Proteins c-akt - metabolism; Rats, Sprague-Dawley; Receptor, trkB - metabolism; Schizophrenia - complications; Schizophrenia - drug therapy; Signal Transduction - drug effects; Spatial Learning; MK-801; cognition impairment; schizophrenia; ω-3 polyunsaturated fatty acids; CREB/BDNF/TrkB pathway
• ISSN: 1672-0733; 1993-1352; 1993-1352
• DOI: 10.1007/s11596-017-1762-4

Summary This study was to determine the protective effect of ω-3 polyunsaturated fatty acids (ω-3PUFAs) on MK-801-induced cognitive impairment in schizophrenia (SZ) rats and the underlying mechanism. A rat model of schizophrenia was induced by MK-801. The cognitive function of rats was assessed using a Morris water maze. The number of hippocampal neurons was measured by Nissl staining. The expression of CREB, p-CREB, BDNF, TrkB, p-TrkB, AKT, p-AKT, ERK, and p-ERK in the hippocampus of rats was detected by Western blotting. The results showed that ω-3PUFAs attenuated MK-801-induced cognitive impairment and hippocampal neurons loss, reversed the injury of the CREB/BDNF/TrkB pathway induced by MK-801, and antagonized MK-801-induced down-regulation of p-AKT and p-ERK in the hippocampus of rats. In conclusion, ω-3PUFAs enhances the CREB/BDNF/TrkB pathway by activating ERK and AKT, thereby increasing the synaptic plasticity and decreasing neuron loss, and antagonizing MK-801-induced cognitive impairment in schizophrenic rats.