Effect of Gymnema montanum leaves on serum and tissue lipids in alloxan diabetic rats
The effect of Gymnema montanum leaves on alloxan-induced hyperlipidemia was studied in male Wistar rats. Ethanolic extract of G. montanum leaves was administered orally and different doses of the extract on blood glucose, serum and tissue lipids, hexokinase, glucose-6-phosphatase, thiobarbituric aci...
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Published in | Experimental diabesity research Vol. 4; no. 3; pp. 183 - 189 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
United States
Hindawi Publishing Corporation
2003
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Subjects | |
Online Access | Get full text |
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Summary: | The effect of Gymnema montanum leaves on alloxan-induced hyperlipidemia was studied in male Wistar rats. Ethanolic extract of G. montanum leaves was administered orally and different doses of the extract on blood glucose, serum and tissue lipids, hexokinase, glucose-6-phosphatase, thiobarbituric acid-reactive substances (TBARS), hydroperoxides, and glutathione in alloxan-induced diabetic rats were studied. G. montanum leaf extract (GLEt) at doses of 50, 100, 200 mg/kg body weight for 3 weeks suppressed the elevated blood glucose and lipid levels in diabetic rats. GLEt at 200 mg/kg body weight was found to be comparable to glibenclamide, a reference drug. These data indicate that G. montanum represents an effective antihyperglycemic and antihyperlipidemic adjunct for the treatment of diabetes and a potential source of discovery of new orally active agent for future therapy. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 1543-8600 2314-6745 2314-6753 1543-8619 |
DOI: | 10.1155/EDR.2003.183 |