The B cell antigen CD75 is a cell surface sialytransferase

In this work we have isolated a cDNA clone encoding the B cell antigen CD75. The amino acid sequence of CD75 is shown to be identical to that of human alpha 2,6 sialyltransferase, believed to be primarily associated with the Golgi complex. This is the first demonstration of cell surface expression o...

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Bibliographic Details
Published inThe Journal of experimental medicine Vol. 172; no. 2; pp. 641 - 643
Main Authors Stamenkovic, I, Asheim, H C, Deggerdal, A, Blomhoff, H K, Smeland, E B, Funderud, S
Format Journal Article
LanguageEnglish
Published United States The Rockefeller University Press 01.08.1990
Subjects
Amino Acid Sequence
Animals
B-Lymphocytes - enzymology
B-Lymphocytes - immunology
Base Sequence
Burkitt Lymphoma
Cell Line
DNA, Neoplasm - genetics
DNA, Neoplasm - isolation & purification
Gene Library
Glycosylation
Humans
Molecular Sequence Data
RNA, Neoplasm - genetics
RNA, Neoplasm - isolation & purification
Sialyltransferases - genetics
Transfection
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Summary:In this work we have isolated a cDNA clone encoding the B cell antigen CD75. The amino acid sequence of CD75 is shown to be identical to that of human alpha 2,6 sialyltransferase, believed to be primarily associated with the Golgi complex. This is the first demonstration of cell surface expression of sialytransferase which, in B cells, may play an important role in intercellular adhesion and antigen presentation events.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0022-1007
1540-9538
DOI:10.1084/jem.172.2.641