6agonist selectivity determinants in somatostatin receptor subtypes I and II
The biological activities of the peptide hormone somatostatin are mediated through a recently identified family of G-protein-linked receptors. A number of somatostatin analogs have been characterized with selective affinities for particular somatostatin receptor subtypes. Using one such molecule (MK...
Saved in:
Published in | The Journal of biological chemistry Vol. 269; no. 40; pp. 24621 - 24626 |
---|---|
Main Authors | , |
Format | Journal Article |
Language | English |
Published |
United States
American Society for Biochemistry and Molecular Biology
07.10.1994
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Summary: | The biological activities of the peptide hormone somatostatin are mediated through a recently identified family of G-protein-linked
receptors. A number of somatostatin analogs have been characterized with selective affinities for particular somatostatin
receptor subtypes. Using one such molecule (MK-678), we have delineated receptor regions that determine analog selectivity
in the murine Type 1 and Type 2 somatostatin receptors. We find that the regions about the second and third extracellular
loops of these two receptors contain the determinants for MK-678 selectivity and affinity. |
---|---|
Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0021-9258 1083-351X |
DOI: | 10.1016/S0021-9258(17)31437-0 |