Assessment of possible association between rs378854 and prostate cancer risk in the Serbian population

Prostate cancer (PCa) is the second most commonly diagnosed cancer among men worldwide. Despite its high incidence rate, the molecular basis of PCa onset and its progression remains little understood. Genome-wide association studies (GWAS) have greatly contributed to the identification of single nuc...

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Bibliographic Details
Published inArchives of biological sciences Vol. 65; no. 2; pp. 475 - 486
Main Authors Brajuskovic, G., Nikolic, Zorana, Kojic, A., Savic-Pavicevic, Dusanka, Cerovic, Snezana, Tomovic, S., Filipovic, Natasa, Vukotic, Vinka, Romac, Stanka
Format Journal Article
LanguageEnglish
Published University of Belgrade, University of Novi Sad 2013
Subjects
association study
polymorphism
Prostate cancer
single nucleotide
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Summary:Prostate cancer (PCa) is the second most commonly diagnosed cancer among men worldwide. Despite its high incidence rate, the molecular basis of PCa onset and its progression remains little understood. Genome-wide association studies (GWAS) have greatly contributed to the identification of single nucleotide polymorphisms (SNP) associated with PCa risk. Several GWAS identified 8q24 as one of the most significant PCa-associated regions. The aim of this study was to evaluate the association of SNP rs378854 at 8q24 with PCa risk in the Serbian population. The study population included 261 individuals diagnosed with PCa, 257 individuals diagnosed with benign prostatic hyperplasia (BPH) and 106 healthy controls. Data quality analysis yielded results showing deviations from Hardy-Weinberg equilibrium in groups of PCa patients and BPH patients as well as in the control group. There was no significant association between alleles and genotypes of the genetic variant rs378854 and PCa risk in the Serbian population.
ISSN:0354-4664
1821-4339
DOI:10.2298/ABS1302475B