Urgent one-stage endoscopic treatment for choledocholithiasis related moderate to severe acute cholangitis: A propensity score-matched analysis

• Published in: World journal of gastroenterology : WJG Vol. 30; no. 15; pp. 2118 - 2127
• Main Authors: Zhou, Yang, Zhang, Yin-Qiu, Huang, Shuai-Jing, Liang, Yan, Liang, Xiao, Wali, Masoom, Feng, Ya-Dong
• Format: Journal Article
• Language: English
• Published: United States 21.04.2024
• Subjects: Acute Disease; Aged; Aged, 80 and over; Anti-Bacterial Agents - therapeutic use; Cholangiopancreatography, Endoscopic Retrograde - adverse effects; Cholangitis - etiology; Cholangitis - surgery; Choledocholithiasis - complications; Choledocholithiasis - diagnosis; Choledocholithiasis - surgery; Feasibility Studies; Female; Humans; Intensive Care Units - statistics & numerical data; Length of Stay - statistics & numerical data; Male; Middle Aged; Propensity Score; Retrospective Studies; Severity of Illness Index; Treatment Outcome; Optimal time; Endoscopic retrograde cholangiopancreatography; One-stage treatment; Acute cholangitis
• ISSN: 1007-9327; 2219-2840
• DOI: 10.3748/wjg.v30.i15.2118

During emergency endoscopic retrograde cholangiopancreatography (ERCP), the safety and feasibility of performing one-stage endoscopic treatment for patients with acute cholangitis (AC) due to choledocholithiasis are unclear. To investigate the safety and feasibility of one-stage endoscopic treatment for moderate to severe AC. We enrolled all patients diagnosed with moderate to severe cholangitis due to common bile duct stones from January 2019 to July 2023. The outcomes were compared in this study between patients who underwent ERCP within 24 h and those who underwent ERCP 24 h later, employing a propensity score (PS) framework. Our primary outcomes were intensive care unit (ICU) admission rates, ICU length of stay, and duration of antibiotic use. In total, we included 254 patients and categorized them into two groups based on the time elapsed between admission and intervention: The urgent group (≤ 24 h, = 102) and the elective group (> 24 h, = 152). Ninety-three pairs of patients with similar characteristics were selected by PS matching. The urgent ERCP group had more ICU admissions (34.4% 21.5%, = 0.05), shorter ICU stays (3 d 9 d, < 0.001), fewer antibiotic use (6 d 9 d, < 0.001), and shorter hospital stays (9 d 18.5 d, < 0.001). There were no significant differences observed in adverse events, in-hospital mortality, recurrent cholangitis occurrence, 30-d readmission rate or 30-d mortality. Urgent one-stage ERCP provides the advantages of a shorter ICU stay, a shorter duration of antibiotic use, and a shorter hospital stay.