HTLV-III Legend Correction

• Published in: Science (American Association for the Advancement of Science) Vol. 232; no. 4748; p. 307
• Main Authors: Gilden, Raymond V., Gonda, Matthew A., Sarngadharan, M. G., Popovic, Mikulas, Gallo, Robert C.
• Format: Journal Article
• Language: English
• Published: United States The American Association for the Advancement of Science 18.04.1986
• Subjects: Acquired Immunodeficiency Syndrome - microbiology; AIDS/HIV; Deltaretrovirus - ultrastructure; HIV; Humans; Legends; Letters; Microscopy, Electron
• ISSN: 0036-8075; 1095-9203
• DOI: 10.1126/science.3008325

We recently reexamined the electron micrographs used in our publications in Science (4 May 1984) and discovered that in the composite micrograph of Schüpbach et al. (figure 4) the panel labeled HTLV-III was inadvertently composed from photographs of a HUT-78 culture transiently infected with a sample of LAV 1 provided by L. Montagnier's laboratory. The LAV 1 preparation was used to transiently infect T cells in one of our laboratories to confirm that it was indeed a retrovirus. In the several months preceding preparation of the composite in question, electron micrographs of cultures infected with our HTLV-III isolates were available from specimens obtained from known ARC and AIDS patients. One appeared in Gao et al. ; others were used in Popovic et al. and Shaw et al. (4). The figure legend in Schupbach et al. was prepared with the intent that particles from patient J.S. shown in Galo et al. (figure 2) were to be used. Thus, this correction relates only to the choice of photographs used in the one communication and not to the content of that paper or any of the other papers.