Linear Electric Traction as an Alternative Model of the Actin/Myosin Motor

Current models for the action of linear biological motors may be grouped in to two main categories. The conventional “bind and bend” models rely for their power stroke upon a structural change in the myosin headgroup (S1 fragment) which follows the binding of myosin of the F-actin filament. The more...

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Bibliographic Details
Published inJournal of theoretical biology Vol. 179; no. 1; pp. 55 - 60
Main Author Edmonds, Donald T.
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 07.03.1996
Subjects
Actins - physiology
Adenosine Diphosphate - metabolism
Adenosine Triphosphate - metabolism
Animals
Electrophysiology
Hydrolysis
Models, Biological
Muscles - physiology
Myosins - physiology
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Summary:Current models for the action of linear biological motors may be grouped in to two main categories. The conventional “bind and bend” models rely for their power stroke upon a structural change in the myosin headgroup (S1 fragment) which follows the binding of myosin of the F-actin filament. The more recent ratchet models demonstrate that directional motion to a particle along an asymmetrical ratchet is possible with a symmetrical but time-correlated stochastic drive. In this paper a new type of model is introduced which is deterministic like the “bind and bend” model but it requires no molecular structural changes to power the stroke. Like the ratchet models the motor is driven along the linear stator by tangential forces at the interface but the forces are electrostatic and controlled by the hydrolysis of ATP to ADP.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:0022-5193
1095-8541
DOI:10.1006/jtbi.1996.0048