Structural Elucidation and Free Radical Scavenging Activity of a new o-Orsellinic Acid Derivative Isolated from the Lichen Cladonia rappii

Rappiidic acid, a new o-orsellinic acid derivative, was isolated from the lichen Cladonia rappii. Its capability to scavenge reactive oxygen species (ROS) and reactive nitrogen species (RNS) was investigated and compared with resveratrol and (+)-usnic acid. Usnic acid at 100 μM was the most efficien...

Full description

Saved in:
Bibliographic Details
Published inNatural product communications Vol. 11; no. 9; p. 1311
Main Authors Lage, Tiago C.A., Horta, Lívia P., Montanari, Ricardo M., Silva, Jefferson G., de Fátima, Ângelo, Fernandes, Sergio A., Modolo, Luzia V.
Format Journal Article
LanguageEnglish
Published Los Angeles, CA SAGE Publications 01.09.2016
Subjects
Superoxide anion
DPPH
Rappiidic acid
Natural products
Cladonia rappii A. Evans
Free radical scavenging
Orsellinic acid
Online AccessGet full text

Cover

More Information
Summary:Rappiidic acid, a new o-orsellinic acid derivative, was isolated from the lichen Cladonia rappii. Its capability to scavenge reactive oxygen species (ROS) and reactive nitrogen species (RNS) was investigated and compared with resveratrol and (+)-usnic acid. Usnic acid at 100 μM was the most efficient ROS scavenger, exhibiting activity 3-fold higher than that of resveratrol. At the same concentration, rappidic acid scavenged 23.1% of ROS formed, demonstrating that this compound is twice as active as resveratrol. Both compounds were shown to be poor RNS scavengers.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1934-578X
1555-9475
DOI:10.1177/1934578X1601100932