15-Year Comparison of Supra-Annular Porcine and PERIMOUNT Aortic Bioprostheses

• Published in: Asian cardiovascular & thoracic annals Vol. 14; no. 3; pp. 200 - 205
• Main Authors: Jamieson, WR Eric, Germann, Eva, Aupart, Michel R, Neville, Paul H, Marchand, Michel A, Fradet, Guy J
• Format: Journal Article
• Language: English
• Published: London, England Asian Soc Cardio Surg 01.06.2006; SAGE Publications
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; Aortic Valve - surgery; Bioprosthesis; Female; Heart Valve Prosthesis; Humans; Male; Middle Aged; Time Factors
• ISSN: 0218-4923; 1816-5370
• DOI: 10.1177/021849230601400306

The second-generation Carpentier-Edwards bioprostheses, the supra-annular porcine valve and the PERIMOUNT pericardial valve, have been evaluated longitudinally for several years. This study compared clinical performance over 15 years. Aortic valve replacement was performed with a supra-annular porcine valve in 1,823 patients (group 1) aged 19–89 years (mean, 68.9 ± 10.9 years) and with a PERIMOUNT pericardial bioprosthesis in 1,430 patients (group 2) aged 16–90 years (mean, 69.5 ± 10.4 years). The groups were similar except for concomitant coronary artery bypass in 43% of group 1 and 18% of group 2 (p < 0.001). Overall survival at 15 years was 29.3% ± 1.5% for group 1 and 35.2% ± 3.1% for group 2 (p = 0.0009). The actual freedom from valve-related mortality was 88.5% ± 0.9% for group 1 and 84.9% ± 1.7% for group 2. The actual freedom from structural valve deterioration at 15 years was similar overall, and for patients aged > 60 years, between the groups, but was dissimilar (group 2 > group 1) for age ≤ 60 years. The predictors of structural valve deterioration were valve type (group 1 > group 2), sex (male > female), age, and concomitant coronary artery bypass. Both bioprostheses provided satisfactory clinical performance at 15 years after aortic valve replacement.