Paradoxical widespread c-Fos expression induced by a GABA agonist in the forebrain of transgenic mice with ectopic expression of the GABAA α6 subunit

• Published in: Neuroscience Vol. 293; pp. 123 - 135
• Main Authors: Hellsten, K.S, Linden, A.-M, Korpi, E.R
• Format: Journal Article
• Language: English
• Published: Elsevier Ltd 07.05.2015
• Subjects: c-Fos; extrasynaptic; GABAA receptor; gaboxadol; Neurology; THIP; transgenic mouse; DG; GABA A receptor; basolateral nucleus of amygdala; central nucleus of amygdala; c-Fos; t-butylbicyclophosphoro[ 35S]thionate; phosphate-buffered saline; transgenic mouse; 4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol, also known as THIP; BSA; CA1 and CA3 areas of hippocampus; MDL; TBPS; PBST20; gaboxadol; bed nucleus of stria terminalis; PBS; PBS containing 0.05% Tween 20; cingulate cortex; lateral part of mediodorsal thalamic nucleus; Cg1; BNST; dentate gyrus; extrasynaptic; [ 35S]TBPS; BLA; γ-aminobutyric acid; t-butylbicyclophosphorothionate; GABA; THIP; bovine serum albumin; CA1 and CA3; CeA; [35S]TBPS; GABAA receptor
• ISSN: 0306-4522; 1873-7544
• DOI: 10.1016/j.neuroscience.2015.02.052

Highlights • Transgenic Thy1α6 mice overexpress extrasynaptic GABAA receptors in the forebrain. • Thy1α6 mice show enhanced sensitivity to anxiolytic effects of gaboxadol. • Gaboxadol paradoxically increased c-Fos expression in the Thy1α6 forebrain. • Especially the central extended amygdala and septum displayed enhanced activation. • Thus, activation of neurons in these regions appeared to mediate the gaboxadol-induced anxiolysis.