Mapping the Landscape of Magnetic Field Effects on Neural Regeneration and Repair: A Combined Systematic Review, Mathematical Model, and Meta-Analysis

Magnetic field exposure is a well-established diagnostic tool. However, its use as a therapeutic in regenerative medicine is relatively new. To better understand how magnetic fields affect neural repair in vitro, we started by performing a systematic review of publications that studied neural repair...

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Published inJournal of tissue engineering and regenerative medicine Vol. 2023; pp. 1 - 15
Main Authors McGraw, Meghan, Gilmer, Gabrielle, Bergmann, Juliana, Seshan, Vishnu, Wang, Kai, Pekker, David, Modo, Michel, Ambrosio, Fabrisia
Format Journal Article
LanguageEnglish
Published Hoboken Hindawi 21.09.2023
Hindawi Limited
Subjects
Cell cycle
Cells (biology)
Dependent variables
Exposure
Independent variables
Magnetic fields
Mathematical analysis
Mathematical models
Meta-analysis
Nervous system
Neural stem cells
Progenitor cells
Regeneration (physiology)
Regenerative medicine
Reproducibility
Simulation
Stem cells
Systematic review
Tissue engineering
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Summary:Magnetic field exposure is a well-established diagnostic tool. However, its use as a therapeutic in regenerative medicine is relatively new. To better understand how magnetic fields affect neural repair in vitro, we started by performing a systematic review of publications that studied neural repair responses to magnetic fields. The 38 included articles were highly heterogeneous, representing 13 cell types, magnetic field magnitudes of 0.0002–10,000 mT with frequencies of 0–150 Hz, and exposure times ranging from one hour to several weeks. Mathematical modeling based on data from the included manuscripts revealed higher magnetic field magnitudes enhance neural progenitor cell (NPC) viability. Finally, for those regenerative processes not influenced by magnitude, frequency, or time, we integrated the data by meta-analyses. Results revealed that magnetic field exposure increases NPC proliferation while decreasing astrocytic differentiation. Collectively, our approach identified neural repair processes that may be most responsive to magnetic field exposure.
ISSN:1932-7005
1932-6254
1932-7005
DOI:10.1155/2023/5038317