Acute Fatal Post-CABG Low Dose Amiodarone Lung Toxicity

Amiodarone is one of the commonly used anti-arrhythmic agents with well-recognized chronic pulmonary toxicity. We present our experience of a patient with a fatal outcome after coronary artery bypass grafting and a short course of amiodarone treatment with a low total cumulative dose for the treatme...

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Bibliographic Details
Published inAsian cardiovascular & thoracic annals Vol. 15; no. 6; pp. e66 - e68
Main Authors Argyriou, Mihalis, Hountis, Panagiotis, Antonopoulos, Nicolaos, Mathioudaki, Maria
Format Journal Article
LanguageEnglish
Published London, England Asian Soc Cardio Surg 01.12.2007
SAGE Publications
Subjects
Acute Disease
Aged
Amiodarone - administration & dosage
Amiodarone - adverse effects
Anti-Arrhythmia Agents - administration & dosage
Anti-Arrhythmia Agents - adverse effects
Atrial Fibrillation - drug therapy
Atrial Fibrillation - etiology
Coronary Artery Bypass - adverse effects
Fatal Outcome
Humans
Infusions, Intravenous
Lung Diseases - chemically induced
Lung Diseases - pathology
Male
Pulmonary Alveoli - drug effects
Pulmonary Alveoli - pathology
Tomography, X-Ray Computed
Treatment Outcome
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Summary:Amiodarone is one of the commonly used anti-arrhythmic agents with well-recognized chronic pulmonary toxicity. We present our experience of a patient with a fatal outcome after coronary artery bypass grafting and a short course of amiodarone treatment with a low total cumulative dose for the treatment of postoperative atrial fibrillation. Necropsy revealed diffuse pulmonary damage due to acute amiodarone lung toxicity.
ISSN:0218-4923
1816-5370
DOI:10.1177/021849230701500626