Comparative study of laparoscopic vs open gastrectomy in gastric cancer management

• Published in: World journal of gastroenterology : WJG Vol. 17; no. 41; pp. 4602 - 4606
• Main Authors: Sica, Giuseppe S, Iaculli, Edoardo, Biancone, Livia, Di Carlo, Sara, Scaramuzzo, Rosa, Fiorani, Cristina, Gentileschi, Paolo, Gaspari, Achille L
• Format: Journal Article
• Language: English
• Published: United States Baishideng Publishing Group Co., Limited 07.11.2011
• Subjects: Adenocarcinoma - pathology; Adenocarcinoma - surgery; Aged; Brief; Female; Gastrectomy - methods; Humans; Laparoscopy - methods; LGS; Longitudinal Studies; Male; Middle Aged; Prospective Studies; Stomach Neoplasms - pathology; Stomach Neoplasms - surgery; Survival Rate; Treatment Outcome; 切除术; 开放式; 生存概率; 管理; 胃癌; 腹腔镜; 随机试验; Long-term outcomes; Laparoscopy; Advanced gastric cancer; Survival; Laparoscopic cancer surgery
• ISSN: 1007-9327; 2219-2840
• DOI: 10.3748/wjg.v17.i41.4602

AIM：To compare long-term results of gastric cancer patients undergoing laparoscopic and open gastrec-tomy in a single unit.METHODS：From February 2000 to September 2004,all patients with adenocarcinoma of the stomach were assessed to entry in this longitudinal prospective non-randomized trial.Primary endpoint was cancer-related survival and secondary endpoints were overall survival,evaluation of surgical complications and mortality.RESULTS：Fifty-eight patients were enrolled.Forty-seven patients were followed-up（range 11-103,me-dian 38 mo）.Four patients were lost at follow up.Twenty-two patients underwent a laparoscopic gastric surgery（LGS）and 25 had a standard open procedure（OGS）.No statistical difference was found between the two groups in terms of 5 years cancer-related mortality rate（50% vs 52%,P = 1）,and 5 years overall mortal-ity rate（54.5% vs 56%,P = 1）.Accordingly,cancer-related and overall survival probability by Kaplan-Meier method showed comparable results（P = 0.81 and P = 0.83,respectively）.We found no differences in surgical complications in the 2 groups.There was no conversion to open surgery in this series.CONCLUSION：LGS is as effective as OGS in the man-agement of advanced gastric cancer.However LGS can-not be recommended routinely over OGS for the treat-ment of advanced gastric cancer.