Erosive and ulcerative stomatitis in dogs and cats: which immune-mediated diseases to consider?

Immune-mediated and autoimmune diseases of the skin often present with oral cavity involvement. Autoimmune subepidermal blistering diseases and pemphigus vulgaris are classic examples. While the primary lesions (vesicles and bullae) are relatively specific, these fragile lesions evolve rapidly into...

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Bibliographic Details
Published inJournal of the American Veterinary Medical Association Vol. 261; no. S1; p. S48
Main Authors Bizikova, Petra, Linder, Keith E, Anderson, Jamie G
Format Journal Article
LanguageEnglish
Published United States 01.06.2023
Subjects
Animals
Cat Diseases
Cats
Dog Diseases - diagnosis
Dogs
Pemphigus - diagnosis
Pemphigus - veterinary
Skin - pathology
Stomatitis - veterinary
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Summary:Immune-mediated and autoimmune diseases of the skin often present with oral cavity involvement. Autoimmune subepidermal blistering diseases and pemphigus vulgaris are classic examples. While the primary lesions (vesicles and bullae) are relatively specific, these fragile lesions evolve rapidly into erosions and ulcers, which are lesion types that overlap with many diseases. Furthermore, some immune-mediated diseases such as severe adverse drug reactions, lupus diseases, canine uveodermatological syndrome, and vasculitis, may or may not involve the oral cavity, and often nonoral clinical manifestations are more diagnostic. In these situations, disease knowledge combined with signalment, lesion distribution, and history help to narrow the differentials. Surgical biopsy is required for confirmation in most diseases, while immunosuppressive treatments most typically involve glucocorticoids with or without nonsteroidal immunosuppressants.
ISSN:1943-569X
DOI:10.2460/javma.22.12.0573