Microwave-assisted synthesis of 2,3-dihydropyrido[2,3-d]pyrimidin-4(1H)-ones catalyzed by DBU in aqueous medium

• Published in: Green chemistry : an international journal and green chemistry resource : GC Vol. 14; no. 4; pp. 945 - 951
• Main Authors: Yang, Liupan, Shi, Daxin, Chen, Shu, Chai, Hongxin, Huang, Danfei, Zhang, Qi, Li, Jiarong
• Format: Journal Article
• Language: English
• Published: CAMBRIDGE Royal Soc Chemistry 01.01.2012; Royal Society of Chemistry
• Subjects: Catalysis; Chemistry; Chemistry, Multidisciplinary; Exact sciences and technology; General and physical chemistry; Green & Sustainable Science & Technology; Heterocyclic compounds; Heterocyclic compounds with only one n hetero atom and condensed derivatives; Heterocyclic compounds with several n hetero atoms in the same ring, in separated rings or in fused rings; Organic chemistry; Physical Sciences; Preparations and properties; Science & Technology; Science & Technology - Other Topics; Theory of reactions, general kinetics. Catalysis. Nomenclature, chemical documentation, computer chemistry; MILD; NEIGHBORING GROUP-INTERACTION; FACILE SYNTHESIS; HETEROCYCLES; ACIDS; EFFICIENT SYNTHESIS; AGENTS; DERIVATIVES; 1,8-Diazabicyclo[5.4.0]undec-7-ene; Water; Catalytic reaction; Nitrile; Nitrogen heterocycle; Microwave; Carbonyl; Ketone; Pyridine derivatives; Amine; Aqueous medium; Preparation; Microwave irradiation; Recycled material; Recycling; Aqueous solution; Chemical synthesis
• ISSN: 1463-9262; 1463-9270
• DOI: 10.1039/c2gc16469h

A clean green, efficient and facile protocol was developed for the synthesis of a series of 2,3-dihydropyrido[2,3-d]pyrimidin-4(1H)-ones in water with good yield by the reaction of 2-amino-nicotinonitriles with carbonyls catalyzed by DBU under microwave irradiation. The DBU-H2O system can be recycled five times without activity loss.