Strobilurin D and strobilurin F: two new cytostatic and antifungal (E)-beta-methoxyacrylate antibiotics from Cyphellopsis anomala (1)

Strobilurin D and strobilurin F, two new cytostatic and antifungal antibiotics of the (E)-beta-methoxyacrylate class, have been isolated from mycelial cultures of the basidiomycete Cyphellopsis anomala (Pers. ex Fr.) Sing. The structures were elucidated by spectroscopic methods. The antibiotics inhi...

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Bibliographic Details
Published inPlanta medica Vol. 56; no. 5; pp. 446 - 450
Main Authors Weber, W, Anke, T, Bross, M, Steglich, W
Format Journal Article
LanguageEnglish
Published Germany 01.10.1990
Subjects
Animals
Antibiotics, Antineoplastic - isolation & purification
Antifungal Agents - isolation & purification
antifungal properties
Basidiomycota
Basidiomycota - analysis
Cells, Cultured
Cricetinae
Fatty Acids, Unsaturated - isolation & purification
Fatty Acids, Unsaturated - pharmacology
HeLa Cells
Humans
Methacrylates
Molecular Structure
plant extracts
Strobilurins
Vesicular stomatitis Indiana virus - drug effects
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Summary:Strobilurin D and strobilurin F, two new cytostatic and antifungal antibiotics of the (E)-beta-methoxyacrylate class, have been isolated from mycelial cultures of the basidiomycete Cyphellopsis anomala (Pers. ex Fr.) Sing. The structures were elucidated by spectroscopic methods. The antibiotics inhibit the growth of human and animal cells and a wide variety of fungi. Like strobilurins A and B, the new metabolites are potent inhibitors of respiration.
ISSN:0032-0943
1439-0221
DOI:10.1055/s-2006-961008