Influence of the R22H variant of macrophage inflammatory protein 1β/Lag-1 in HIV-1 survival
The chemokine macrophage inflammatory protein 1 beta /CCL4, ligand of the major HIV co-receptor CCR5, is encoded by two genes, Act-2 and Lag-1. Our work focused on R22H, a variant of Lag-1 located near the N-loop, in the 3 sub(10) turn, a domain essential for interacting with CCR5. We observed that...
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Published in | AIDS (London) Vol. 19; no. 8; pp. 831 - 833 |
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Main Authors | , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Hagerstown, MD
Lippincott Williams & Wilkins
20.05.2005
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Subjects | |
Online Access | Get full text |
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Summary: | The chemokine macrophage inflammatory protein 1 beta /CCL4, ligand of the major HIV co-receptor CCR5, is encoded by two genes, Act-2 and Lag-1. Our work focused on R22H, a variant of Lag-1 located near the N-loop, in the 3 sub(10) turn, a domain essential for interacting with CCR5. We observed that HIV-1-infected patients from the SEROCO cohort, bearing the R22H variant either at the homozygous or heterozygous state, exhibit a worse global survival compared with wild-type homozygous individuals. |
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Bibliography: | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 |
ISSN: | 0269-9370 1473-5571 |
DOI: | 10.1097/01.aids.0000168979.97584.18 |