Influence of the R22H variant of macrophage inflammatory protein 1β/Lag-1 in HIV-1 survival

The chemokine macrophage inflammatory protein 1 beta /CCL4, ligand of the major HIV co-receptor CCR5, is encoded by two genes, Act-2 and Lag-1. Our work focused on R22H, a variant of Lag-1 located near the N-loop, in the 3 sub(10) turn, a domain essential for interacting with CCR5. We observed that...

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Published inAIDS (London) Vol. 19; no. 8; pp. 831 - 833
Main Authors CAPOULADE-METAY, Corinne, MEYER, Laurence, TRAN, Ton, PERSOZ, Anne, BOURDAIS, Anne, DUDOIT, Yasmine, DELFRAISSY, Jean-Francois, DEBRE, Patrice, THEODOROU, Ioannis
Format Journal Article
LanguageEnglish
Published Hagerstown, MD Lippincott Williams & Wilkins 20.05.2005
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Summary:The chemokine macrophage inflammatory protein 1 beta /CCL4, ligand of the major HIV co-receptor CCR5, is encoded by two genes, Act-2 and Lag-1. Our work focused on R22H, a variant of Lag-1 located near the N-loop, in the 3 sub(10) turn, a domain essential for interacting with CCR5. We observed that HIV-1-infected patients from the SEROCO cohort, bearing the R22H variant either at the homozygous or heterozygous state, exhibit a worse global survival compared with wild-type homozygous individuals.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ISSN:0269-9370
1473-5571
DOI:10.1097/01.aids.0000168979.97584.18