The effect of CYP2C19 gene polymorphism on the eradication rate of Helicobacter pylori by proton pump inhibitors-containing regimens in Asian populations: a meta-analysis

• Published in: Pharmacogenomics Vol. 22; no. 13; pp. 859 - 879
• Main Authors: Fu, Juan, Sun, Chang-Feng, He, Hong-Yan, Ojha, Suvash Chandra, Shi, Han, Deng, Cun-Liang, Sheng, Yun-Jian
• Format: Journal Article
• Language: English
• Published: England 01.08.2021
• Subjects: Asians; Cohort Studies; Cytochrome P-450 CYP2C19 - genetics; Helicobacter Infections - drug therapy; Helicobacter Infections - genetics; Helicobacter pylori; Humans; Polymorphism, Genetic - genetics; Proton Pump Inhibitors - therapeutic use; Randomized Controlled Trials as Topic; proton pump inhibitors; polymorphism; Helicobacter pylori; CYP2C19; Asia; eradication

The effects of proton pump inhibitors (PPI) depend on metabolic enzyme that has different activity due to gene polymorphism. The purpose of this meta-analysis is to determine the potential effects of polymorphism on the efficiency of PPI-based treatment. The PubMed, EMBASE, Cochrane Library, etc. we...