The effect of CYP2C19 gene polymorphism on the eradication rate of Helicobacter pylori by proton pump inhibitors-containing regimens in Asian populations: a meta-analysis
The effects of proton pump inhibitors (PPI) depend on metabolic enzyme that has different activity due to gene polymorphism. The purpose of this meta-analysis is to determine the potential effects of polymorphism on the efficiency of PPI-based treatment. The PubMed, EMBASE, Cochrane Library, etc. we...
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Published in | Pharmacogenomics Vol. 22; no. 13; pp. 859 - 879 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
Published |
England
01.08.2021
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Subjects | |
Online Access | Get full text |
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Summary: | The effects of proton pump inhibitors (PPI) depend on metabolic enzyme
that has different activity due to gene polymorphism. The purpose of this meta-analysis is to determine the potential effects of
polymorphism on the efficiency of PPI-based treatment.
The PubMed, EMBASE, Cochrane Library, etc. were searched for relevant articles published in English or Chinese from inception to 31 May 2020. Finally, 26 randomized controlled trials and 15 cohort studies met the inclusion criteria and used for the meta-analysis via STATA version 15.
Poor metabolizer (PM) genotype
eradication rates were highest for Asian individuals receiving triple or quadruple first-line therapy based on PPIs (p < 0.05).
polymorphism could influence
eradication rate only in Mainland China and Japan (p < 0.05).
PM genotype facilitates the elimination of
in Asian populations. Rabeprazole-, esomeprazole- and pantoprazole-based eradication program was less affected by the
polymorphism. |
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Bibliography: | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Undefined-3 |
ISSN: | 1462-2416 1744-8042 |
DOI: | 10.2217/pgs-2020-0127 |