Myopia Control Using Toric Orthokeratology (TO-SEE Study)

• Published in: Investigative ophthalmology & visual science Vol. 54; no. 10; p. 6510
• Main Authors: Chen, Connie, Cheung, Sin Wan, Cho, Pauline
• Format: Journal Article
• Language: English
• Published: United States 03.10.2013
• Subjects: Astigmatism - complications; Astigmatism - physiopathology; Astigmatism - therapy; Child; Contact Lenses; Cornea - pathology; Cornea - physiopathology; Corneal Topography; Equipment Design; Female; Follow-Up Studies; Humans; Male; Myopia - complications; Myopia - physiopathology; Myopia - therapy; Orthokeratologic Procedures - methods; Refraction, Ocular - physiology; Treatment Outcome; Visual Acuity; myopia; astigmatism; orthokeratology; myopia control; toric design
• ISSN: 1552-5783; 1552-5783
• DOI: 10.1167/iovs.13-12527

This nonrandomized clinical study aimed to investigate the effectiveness of toric orthokeratology (ortho-k) for myopia control in myopic children with moderate-to-high astigmatism We enrolled 80 subjects (aged 6-12 years; ortho-k, 43; control, 37) with myopia of 0.50 to 5.00 diopters (D), and with-the-rule astigmatism of -1.25 to -3.50 D, and unremarkable ocular and general conditions. Data collection, including visual acuity, subjective and objective refraction, axial length, corneal topography, and biomicroscopy examination, was performed every 6 months during the 24-month study period. Results from the right eye or the eye with higher astigmatism were reported. A total of 35 ortho-k and 23 control subjects completed the study successfully. Subjects in both groups demonstrated axial elongation (P < 0.001). The average axial elongation at the end of study was 0.31 ± 0.27 and 0.64 ± 0.31 mm in the ortho-k and control groups, respectively (P < 0.001). At the end of 24 months, axial elongation in ortho-k subjects was 52% slower than that in the control group. Axial elongation was correlated significantly with the initial age of the subjects (P = 0.02) and treatment assigned (P = 0.04), but not with sex, initial myopia, initial refractive cylinder, or initial corneal toricity (P > 0.08). Toric ortho-k lenses can slow axial elongation effectively in myopic children with moderate-to-high astigmatism. (ClinicalTrials.gov number, NCT00978692.).