Long-Term Oncological Outcomes of Endoscopic Stenting as a Bridge to Surgery Versus Emergency Surgery for Malignant Colorectal Obstruction: A Comparative Study

• Published in: Journal of laparoendoscopic & advanced surgical techniques. Part A Vol. 27; no. 6; p. 611
• Main Authors: Yan, Fei-Hu, Lou, Zheng, Liu, Xiao-Shuang, Wang, Zhen, Xu, Xiao-Dong, Gao, Yong-Jun-Yi, He, Jian, Wang, Hao, Fu, Chuan-Gang, Zhang, Wei, He, Hai-Yan, Cai, Bei-Li, Yu, En-da
• Format: Journal Article
• Language: English
• Published: United States 01.06.2017
• Subjects: Case-Control Studies; Chemotherapy, Adjuvant; China; Colorectal Neoplasms - mortality; Colorectal Neoplasms - surgery; Elective Surgical Procedures - methods; Emergencies; Endoscopy - methods; Female; Humans; Intestinal Obstruction - mortality; Intestinal Obstruction - surgery; Male; Middle Aged; Retrospective Studies; Stents; Survival Analysis; oncological outcomes; stent; emergencies; colorectal cancer; bowel obstruction
• ISSN: 1557-9034
• DOI: 10.1089/lap.2016.0529

With consideration of the theoretical link between the stent insertion and the increased risk of tumor cells spillaged, which may lead to distant metastases, there is a concern about long-term clinical outcomes after the usage of self-expanding metallic stents (SEMS) as a "bridge to surgery" in the malignant colorectal obstruction (MCO) treatment. This cohort study aimed to compare the long-term oncological outcomes of SEMS as a bridge to surgery (SEMS group) with those of emergency surgery (ES group) for MCO. Twenty-seven patients who underwent semielective curative resection after endoscopic SEMS insertion were included from October 2007 to December 2012 in the SEMS group were compared with 33 patients who underwent emergency curative surgery for MCO during the same period in the ES group. The clinical pathologic characteristics and the overall survival (OS) rate were compared between the two groups. There were no significant differences in demographics, tumor stage, location, and histology between the SEMS and ES groups. The median OS times were 37 months for the SEMS group and 23 months for the ES group. The proportions of patients who received postoperative adjuvant chemotherapy were comparable (SEMS group versus ES group, 70.4% versus 45.5%; P = .138). There were no significant differences in terms of the long-term oncological outcome between two groups in the 3-year OS rate (55.6% versus 39.4%; P = .2119) and the 5-year OS rate (48.1% versus 36.4%; P = .3570). Long-term oncological outcomes of the SEMS group were comparable to those of the ES group.