Toxoplasma gondii infection and pre-eclampsia among Sudanese women
Pre-eclampsia is the main cause of maternal and perinatal adverse effects. Although the exact mechanism and pathophysiology of pre-eclampsia are not yet fully understood, there are recent studies on the association between various infections and pre-eclampsia. This study investigated the association...
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Published in | Transactions of the Royal Society of Tropical Medicine and Hygiene Vol. 112; no. 8; pp. 393 - 396 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
England
01.08.2018
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Online Access | Get full text |
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Summary: | Pre-eclampsia is the main cause of maternal and perinatal adverse effects. Although the exact mechanism and pathophysiology of pre-eclampsia are not yet fully understood, there are recent studies on the association between various infections and pre-eclampsia. This study investigated the association between maternal Toxoplasma gondii infection and pre-eclampsia.
A case-control study was conducted at Saad Abualila Hospital, Khartoum, Sudan. The cases were pregnant women with pre-eclampsia and the controls were healthy pregnant women. Their obstetrics history was collected using a questionnaire. T. gondii antibodies (immunoglobulin G [IgG] and IgM) were analysed in the maternal serum of both the cases and the controls using enzyme-linked immunosorbent assay.
Maternal age and parity were not different between the cases and controls (90 women in each arm). There was a significant difference in the maternal anti-T. gondii IgG seropositivity, which was higher in the cases (pre-eclampsia) compared with the controls (32.3% vs 4.4%; p<0.001). There was no significant difference in the IgM seropositivity for T. gondii between the cases and controls (3.3% vs 1.1%; p=0.621). Binary logistic regression showed that women with toxoplasma IgG seropositivity were at higher risk for pre-eclampsia (odds ratio 9.40 [95% confidence interval 3.01 to 29.32]; p<0.001).
In the current study, T. gondii infection seems to be associated with pre-eclampsia. Further research is needed. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0035-9203 1878-3503 |
DOI: | 10.1093/trstmh/try067 |