Synthesis and Antimicrobial Activities of New S-Nucleosides of Chromeno[2,3-B]Pyridine Derivatives and C-Nucleosides of [1,2,4]Triazolo[1,5-A]Quinoline Derivatives

• Published in: Nucleosides, nucleotides & nucleic acids Vol. 33; no. 9; pp. 583 - 596
• Main Authors: Ghoneim, Amira A., El-Farargy, Ahmed F., Abdelaziz, Sahar
• Format: Journal Article
• Language: English
• Published: PHILADELPHIA Taylor & Francis 01.01.2014
• Subjects: [1,2,4]triazolo[1,5-a]quinolines; Anti-Infective Agents - chemical synthesis; Anti-Infective Agents - pharmacology; antimicrobial activity; Biochemistry & Molecular Biology; Chromeno[2,3-b]pyridines; Escherichia coli - drug effects; l-rhamnopy-ranosyl bromide; Life Sciences & Biomedicine; Molecular Structure; Nucleosides - chemical synthesis; Nucleosides - pharmacology; Science & Technology; Staphylococcus aureus - drug effects; DESIGN; KETENES; Chromeno[2,3-b]pyridines; ANALOGS; L-rhamnopyranosyl bromide; CONVENIENT; antimicrobial activity; QUINOLINE; POTENT; PYRAN DERIVATIVES; BIOLOGICAL EVALUATION; INHIBITORS; N,N-DISUBSTITUTED ALPHA-AMINOMETHYLENEKETONES; [1,2,4]triazolo[1,5-a]quinolines; l-rhamnopy-ranosyl bromide
• ISSN: 1525-7770; 1532-2335
• DOI: 10.1080/15257770.2014.912320

Direct preparation of 2-amino-5,6,7,8-tetrahydro-4-(4-methoxyphenyl)-7,7-dimethyl-5-oxo-4H-chromene-3-carbonitrile 2 and 1,2-diamino-1,4,5,6,7,8-hexahydro-4-(4-methoxyphenyl)-7,7-dimethyl-5-oxo-3-quinolinecarbonitrile 11, which were utilized as starting products for the synthesis of S-nucleoside analogues 10 and 15 and C-nucleoside analogues 12 and 13, is presented in the current study. The antibacterial and antifungal activities of these new compounds were evaluated. The structures of the new products were confirmed on the basis of elemental and spectral analysis results.