Using Peritumor and Intratumor Vascularity on Preoperative Imaging to Predict Fuhrman Grade Histology of Renal Tumors

• Published in: Journal of endourology
• Main Authors: Ghiraldi, Eric, Nguyen, Justin, Buck, Matthew, Nair, Hari, Israel, Gary, Singh, Dinesh
• Format: Journal Article
• Language: English
• Published: United States 01.11.2022
• ISSN: 1557-900X
• DOI: 10.1089/end.2022.0069

Objective To investigate if peri-tumor and/or intra-tumor vasculature is associated with high grade tumor histology for renal cell carcinoma. Methods A retrospective review at a tertiary care facility was performed of patients who underwent radical nephrectomy or partial nephrectomy for a renal tumor between January 2015 to December 2020. Data of tumor characteristics was collected from final pathology reports. A single radiologist specializing in genitourinary imaging reviewed all pre-operative cross-sectional imaging for peri-tumor vessels and intra-tumor vessels. Single and multivariable logistic regression was utilized to identify variables associated with high grade tumor histology. Results The average tumor size on final pathology was 6.4 cm (Range 3.0-17.0 cm). Ninety-two patients (56.1%) had either an enlarged peri-tumor vessel (n=72), an intra-tumor vessel (n=3), or both a peri-tumor vessel and an intra-tumor vessel (n=17). Of the 92 patients with either a peri-tumor vessel or both a peri-tumor vessel and intra-tumor vessel, 60.9% of these patients had high Fuhrman grade histology on final pathology (60.9% vs 39.1%, p<0.001). Pathologic stage T1a tumors with an enlarged peri-tumor vessel on pre-operative imaging were associated with high Fuhrman grade histology (58.3% vs 41.7%, p=0.015). Across all stages, the presence of an enlarged peritumor vessel was significantly associated with high Fuhrman grade (OR: 2.37, 95% CI 1.17 - 4.9, p = 0.01). Conclusion Findings suggest that vessels surrounding small renal tumors and large renal tumors is associated with high tumor grade (FG > 3). Further research is needed to support the association of peri-tumor vessels with high tumor grade.