Discovery of a novel class of small-molecule antibacterial agents against Staphylococcus aureus

With constantly increasing resistance against the known antibiotics, the search for novel antibacterial compounds is a challenge. The number of synthetic antibacterial agents is limited. We discovered novel small-molecule antibacterial agents that are accessible a simple two-step procedure. The eval...

Full description

Saved in:
Bibliographic Details
Published inFuture medicinal chemistry Vol. 14; no. 5; pp. 299 - 305
Main Authors Kreutzer, David, Gehrmann, Robin, Kincses, Annámaria, Szemerédi, Nikoletta, Spengler, Gabriella, Molnár, Josef, Hilgeroth, Andreas
Format Journal Article
LanguageEnglish
Published England 01.03.2022
Subjects
Online AccessGet full text

Cover

Loading…
More Information
Summary:With constantly increasing resistance against the known antibiotics, the search for novel antibacterial compounds is a challenge. The number of synthetic antibacterial agents is limited. We discovered novel small-molecule antibacterial agents that are accessible a simple two-step procedure. The evaluation against showed antibacterial effects depending on the substituent positioning at the residues of the molecular scaffold. Additionally, we investigated the potential of the compounds to increase the antibacterial activity of tetracycline. The most effective antibacterial compounds possessed a 3-methoxy function at an aromatic residue. In combination with tetracycline, we found a strong effect for a few compounds in boosting the antibacterial activity, so the first promising lead compounds with dual activities could be identified.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1756-8919
1756-8927
DOI:10.4155/fmc-2021-0272