Discovery of a novel class of small-molecule antibacterial agents against Staphylococcus aureus
With constantly increasing resistance against the known antibiotics, the search for novel antibacterial compounds is a challenge. The number of synthetic antibacterial agents is limited. We discovered novel small-molecule antibacterial agents that are accessible a simple two-step procedure. The eval...
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Published in | Future medicinal chemistry Vol. 14; no. 5; pp. 299 - 305 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
Published |
England
01.03.2022
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Subjects | |
Online Access | Get full text |
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Summary: | With constantly increasing resistance against the known antibiotics, the search for novel antibacterial compounds is a challenge. The number of synthetic antibacterial agents is limited.
We discovered novel small-molecule antibacterial agents that are accessible
a simple two-step procedure. The evaluation against
showed antibacterial effects depending on the substituent positioning at the residues of the molecular scaffold. Additionally, we investigated the potential of the compounds to increase the antibacterial activity of tetracycline.
The most effective antibacterial compounds possessed a 3-methoxy function at an aromatic residue. In combination with tetracycline, we found a strong effect for a few compounds in boosting the antibacterial activity, so the first promising lead compounds with dual activities could be identified. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 1756-8919 1756-8927 |
DOI: | 10.4155/fmc-2021-0272 |