Evaluation of the acute toxicity of silahydrocarbon

• Published in: American Industrial Hygiene Association journal Vol. 52; no. 11; p. 469
• Main Authors: Kinkead, E R, Bunger, S K, Wolfe, R E, Doarn, C R
• Format: Journal Article
• Language: English
• Published: United States 01.11.1991
• Subjects: Animals; Eye - drug effects; Female; Guinea Pigs; Lung - drug effects; Male; Rabbits; Rats; Rats, Inbred F344; Silanes - toxicity; Skin - drug effects
• ISSN: 0002-8894; 2163-369X
• DOI: 10.1080/15298669191365063

Silahydrocarbon (SHC) is a base stock for a candidate high-temperature hydraulic fluid. Because United States Air Force personnel working with SHC may be exposed to potential health hazards, a complete battery of acute toxicity tests was performed with the fluid. A single neat dose of 0.1 mL SHC into New Zealand White (NZW) rabbit eyes resulted in slight conjunctival irritation 1 hr after treatment in all unflushed eyes and one of three flushed eyes. Conjunctival irritation persisted through 24 hr but dissipated by 48 hr. Rinsing the eyes after treatment was of questionable benefit. A single treatment of 0.5 mL neat SHC to rabbit skin produced negative results for all but a single animal, which had very slight erythema at the test site 48 hr after treatment. Guinea pigs failed to exhibit a sensitization response following repeated application of SHC. A single oral dose of 5 g SHC/kg body weight given to five male and five female F-344 rats and a single dermal dose of 2 g SHC/kg body weight applied to five male and five female NZW rabbits resulted in no deaths or signs of toxic stress. Five male and five female F-344 rats were exposed to 4.8 mg/L (near limit concentration) of aerosolized SHC for 4 hr. All male rats and four female rats survived. During exposure, the animals exhibited signs of eye and upper respiratory irritation.