A Comprehensive Network Map of Interleukin-26 Signaling Pathway

Interleukin-26 (IL-26) is a cytokine that belongs to the IL-20 subfamily and is primarily expressed in T helper 1 cells and Th17 memory CD4 cells. Its receptor complex, consisting of IL-20R1 and IL-10R2, activates a signaling pathway involving several proteins such as Janus kinase 1 and tyrosine-pro...

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Bibliographic Details
Published inJournal of interferon & cytokine research Vol. 44; no. 9; p. 408
Main Authors Suchitha, G P, Dagamajalu, Shobha, Keshava Prasad, Thottethodi Subrahmanya, Devasahayam Arokia Balaya, Rex
Format Journal Article
LanguageEnglish
Published United States 01.09.2024
Subjects
Animals
Humans
Interleukins - genetics
Interleukins - immunology
Interleukins - metabolism
Signal Transduction - immunology
proinflammatory cytokine
protein–protein interactions
post-translational modifications
immune response
inflammation
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Summary:Interleukin-26 (IL-26) is a cytokine that belongs to the IL-20 subfamily and is primarily expressed in T helper 1 cells and Th17 memory CD4 cells. Its receptor complex, consisting of IL-20R1 and IL-10R2, activates a signaling pathway involving several proteins such as Janus kinase 1 and tyrosine-protein kinase, signal transducer and activator of transcription (STAT) 1, and STAT3. This leads to the initiation of downstream signaling cascades that play a crucial role in various biological processes, including inflammation, immune response regulation, atopic dermatitis, macrophage differentiation, osteoclastogenesis, antibacterial host defense, anti-apoptosis, and tumor growth. In this study, we curated literature data pertaining to IL-26 signaling. The curated map includes a total of seven activation/inhibition events, 16 catalysis events, 33 gene regulation events, 25 protein expression types, two transport events, and three molecular associations.
ISSN:1557-7465
DOI:10.1089/jir.2024.0026