Higher Regional Gray Matter Volume and White Matter Integrity in Individuals With Central Neuropathic Pain After Spinal Cord Injury

• Published in: Journal of neurotrauma Vol. 41; no. 7-8; p. 836
• Main Authors: Livny, Abigail, Golan, Yael, Itzhaki, Nofar, Grossberg, Dafna, Tsarfaty, Galia, Bondi, Moshe, Zeilig, Gabriel, Defrin, Ruth
• Format: Journal Article
• Language: English
• Published: United States 01.04.2024
• Subjects: Brain - pathology; Cross-Sectional Studies; Diffusion Tensor Imaging - methods; Gray Matter - diagnostic imaging; Gray Matter - pathology; Humans; Neuralgia - diagnostic imaging; Neuralgia - etiology; Spinal Cord Injuries - complications; Spinal Cord Injuries - diagnostic imaging; Spinal Cord Injuries - pathology; White Matter - diagnostic imaging; White Matter - pathology; spinal cord injury; structural differences; diffusion tensor imaging; neuropathic pain; voxel-based morphometry; neuroimaging
• ISSN: 1557-9042
• DOI: 10.1089/neu.2023.0146

Spinal cord injury (SCI) is a debilitating neurological condition that often leads to central neuropathic pain (CNP). As the fundamental mechanism of CNP is not fully established, its management is one of the most challenging problems among people with SCI. To shed more light on CNP mechanisms, the aim of this cross-sectional study was to compare the brain structure between individuals with SCI and CNP and those without CNP by examining the gray matter (GM) volume and the white matter (WM) integrity. Fifty-two individuals with SCI-28 with CNP and 24 without CNP-underwent a magnetic resonance imaging (MRI) session, including a T1-weighted scan for voxel-based morphometry, and a diffusion-weighted imaging (DWI) scan for WM integrity analysis, as measured by fractional anisotropy (FA) and mean diffusivity (MD). We found significantly higher GM volume in individuals with CNP compared with pain-free individuals in the right superior (  < 0.0014) and middle temporal gyri (  < 0.0001). Moreover, individuals with CNP exhibited higher WM integrity in the splenium of the corpus callosum (  < 0.0001) and in the posterior cingulum (  < 0.0001), compared with pain-free individuals. The results suggest that the existence of CNP following SCI is associated with GM and WM structural abnormalities in regions involved in pain intensification and spread, and which may reflect maladaptive neural plasticity in CNP.