The relationship between CYP7A1 polymorphisms, coronary artery disease & serum lipid markers

Polymorphic variants of the gene can increase the risk of atherosclerosis-based coronary artery disease (CAD) and modify serum lipid markers. We studied haplotype-tagging single nucleotide polymorphisms of in the Caucasian population and if they are associated with CAD, its symptoms, and any of its...

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Published inBiomarkers in medicine Vol. 13; no. 14; pp. 1199 - 1208
Main Authors Iwanicki, Tomasz, Balcerzyk, Anna, Niemiec, Paweł, Trautsolt, Wanda, Grzeszczak, Władysław, Ochalska-Tyka, Anna, Krauze, Jolanta, Nowak, Tomasz, Żak, Iwona
Format Journal Article
LanguageEnglish
Published England 01.10.2019
Subjects
coronary artery disease
CYP7A1
total cholesterol
myocardial infarction
low-density lipoprotein
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Summary:Polymorphic variants of the gene can increase the risk of atherosclerosis-based coronary artery disease (CAD) and modify serum lipid markers. We studied haplotype-tagging single nucleotide polymorphisms of in the Caucasian population and if they are associated with CAD, its symptoms, and any of its risk factors. We did not find the genetic variants of to be associated with an increased risk of CAD. However, we did find that the common rs3808607 variant is associated with modified concentrations of serum total cholesterol and LDL. We also found that the C allele and the CC genotype of the rs11786580 are more frequent in patients with myocardial infarction. This association was especially strong after the group differentiation by sex.
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ISSN:1752-0363
1752-0371
DOI:10.2217/bmm-2018-0462