Transcriptional landscape of TRPV1, TRPA1, TRPV4, and TRPM8 channels throughout human tissues

• Published in: Life sciences (1973) Vol. 308; p. 120977
• Main Authors: Kudsi, Sabrina Qader, Piccoli, Bruna Candia, Ardisson-Araújo, Daniel, Trevisan, Gabriela
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 01.11.2022
• Subjects: Bioinformatics; Biomarkers; bladder; carcinogenesis; data collection; Dorsal root ganglia; Drug development; duodenum; genetic databases; humans; kidneys; National Center for Biotechnology Information; RNA-sequencing; sequence analysis; transcription (genetics); transient receptor potential vanilloid channels; TRP channels; RPKM; 4aPDD; AITC; H2O2; OTR; Drug development; ANKTM; TRP; Dorsal root ganglia; 4-HNE; RNA-seq; TRPC; CSF; NCBI; TRPP; TRPM8; TRPM; SP; Bioinformatics; AA; TRPA1; TRPV1; S.E.M; TRP channels; RNA-sequencing; TG; PACS2; PAR2; EET; MMP-1; ND; TRPV4; TRPML; DRG; Biomarkers; CGRP; FC; COPD
• ISSN: 0024-3205; 1879-0631; 1879-0631
• DOI: 10.1016/j.lfs.2022.120977

This article aims to analyze the baseline distribution of TRPA1, TRPV1, TRPV4, and TRPM8 channels in human systems at the transcriptional level. Using the RNA-seq dataset from the National Center for Biotechnology Information (NCBI) gene database, we investigated and compared the transcriptional levels of TRPV1, TRPA1, TRPV4 and TRPM8 found in 95 human subjects representing 33 different tissues to determine the tissue specificity of all protein-coding genes. In this study, we observed higher transcriptional levels for TRPV1 (duodenum), TRPA1 (Urinary bladder), TRPV4 (Kidney) and TRPM8 (Prostate) compared to the other TRPs. These channels are involved in developing inflammatory and painful pathologies and seem to participate in cancer development. This information on transcriptional levels of TRPV1, TRPA1, TRPV4 and TRPM8 in human systems may provide essential suggestions for further studies on these proteins. •Duodenum had higher TRPV1 transcripts level than other TRPs.•Urinary bladder showed up higher TRPA1 transcripts than other TRPs.•Kidney had higher TRPV4 transcripts than other TRPs.•TRPM8 transcripts level was higher in the prostate than in other TRPs.