Molecular HIV Surveillance: Beyond Cluster Detection and Response

There has been significant controversy surrounding the use of HIV sequence data to identify outbreaks of HIV transmission since the initiation of molecular HIV surveillance (MHS) in the US. The current approach to MHS is comprehensive cluster detection and response (CDR), in which clusters of relate...

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Bibliographic Details
Published inAIDS research and human retroviruses Vol. 41; no. 4; p. 175
Main Authors Mehta, Sanjay R, Chaillon, Antoine, Wells, Alan B, Little, Susan J
Format Journal Article
LanguageEnglish
Published United States 01.04.2025
Subjects
Cluster Analysis
Disease Outbreaks
Epidemiological Monitoring
HIV - classification
HIV - genetics
HIV - isolation & purification
HIV Infections - epidemiology
HIV Infections - transmission
HIV Infections - virology
Humans
Molecular Epidemiology - methods
United States - epidemiology
United States
molecular epidemiology
clustering
HIV
monitoring
prevention
public health
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Summary:There has been significant controversy surrounding the use of HIV sequence data to identify outbreaks of HIV transmission since the initiation of molecular HIV surveillance (MHS) in the US. The current approach to MHS is comprehensive cluster detection and response (CDR), in which clusters of related infections are identified and used as the basis for cluster-based or population-based interventions. With CDR, there are ethical and stigma concerns around the impingement of individual privacy, as well as legal concerns around the inference of transmission in regions where HIV criminalization laws and statutes exist. Here we propose an alternative approach to the analysis of HIV sequence and public health data that focuses on regions and populations rather than clusters, and still provides useful data for public health agencies.
ISSN:1931-8405
DOI:10.1089/aid.2024.0084