Skin Absorption of Ethylene Oxide Gas Following Exposures Relevant to HAZMAT Incidents

• Published in: Annals of work exposures and health Vol. 61; no. 5; p. 589
• Main Authors: Heath, Linda, Gaskin, Sharyn, Pisaniello, Dino, Crea, Joseph, Logan, Michael, Baxter, Christina
• Format: Journal Article
• Language: English
• Published: England 01.06.2017
• Subjects: Chemical Hazard Release; Chromatography, Gas; Disinfectants - metabolism; Ethylene Oxide - metabolism; Gases - metabolism; Humans; Skin - metabolism; Skin Absorption; Textiles - analysis; chemical incident; fabric interaction; HAZMAT; theoretical models; dermal; in vitro
• ISSN: 2398-7316
• DOI: 10.1093/annweh/wxx030

Ethylene oxide (EO) is a reactive gas used by numerous industries and medical facilities as a sterilant, a fumigant, and as a chemical intermediate in chemical manufacturing. Due to its common use, EO has been involved in a number of leaks and explosive incidents/accidents requiring HAZMAT response. However, the extent of skin absorption under short-term HAZMAT conditions has not been directly assessed. Such data would assist decision making by first responders regarding skin decontamination in EO HAZMAT incidents. An in vitro test protocol with human skin was used for EO exposures at 800 ppm and 3000 ppm. No evidence of dermal penetration was seen for 800 ppm EO during a 30-min challenge. For 3000 ppm, EO penetration was observed after 20 min and was greater under higher temperature/humidity conditions. Fabric (heavy cotton) on skin enhanced penetration 5-fold compared with naked skin. Off gassing from exposed fabric was rapid. The results show dermal uptake of EO vapour from exposure at 3000 ppm is small but clothing may contribute to further dermal absorption/penetration over time. For exposed, but asymptomatic, persons in EO HAZMAT incidents first responders should remove bulky clothing to prevent potential skin damage and further uptake.