Chronic Kidney Disease and Accelerated Decline of Renal Function in Older Adults with HIV in Northern Thailand

• Published in: AIDS research and human retroviruses Vol. 39; no. 12; p. 677
• Main Authors: Aurpibul, Linda, Paklak, Wason, Taecharoenkul, Sineenart, Rerkasem, Amaraporn, Srithanaviboonchai, Kriengkrai
• Format: Journal Article
• Language: English
• Published: United States 01.12.2023
• Subjects: Aged; Female; Glomerular Filtration Rate; HIV Infections - complications; HIV Infections - drug therapy; HIV Infections - epidemiology; Humans; Kidney; Male; Renal Insufficiency, Chronic - complications; Renal Insufficiency, Chronic - epidemiology; Thailand - epidemiology; Thailand; renal function; chronic kidney disease; Thailand; glomerular filtration rate; older adults with HIV
• ISSN: 1931-8405
• DOI: 10.1089/aid.2023.0032

Kidney disease remains prevalent in people living with HIV even in the antiretroviral treatment era. We determine the frequency of chronic kidney disease (CKD), rate of renal function decline, and associated factors in older adults with HIV (OAHIV) aged ≥50 years in northern Thailand. We used data from the medical records and calculated the estimated glomerular filtration rate (eGFR) using the Chronic Kidney Disease Epidemiology Collaboration equation. Of the 269 participants (58% women, 61.8 years median age), 7.1% had CKD (eGFR <60 mL/min per 1.73 m ). There were 21 OAHIV (7.8%) with >25% decline in eGFR in the past year, 90 (33%) with accelerated (>5 mL/min per 1.73 m per year), and 44 (16%) with rapid (>10 mL/min per 1.73 m per year) declining eGFR. Female gender was the only factor associated with an accelerated decline in eGFR (odds ratio, 2.307; 95% confidence interval, 1.331-3.998;  = .003). Continuous monitoring of renal function is recommended for OAHIV to guide treatment modification and intervention.