Elevated CSF free kappa light chains correlate with disability prognosis in multiple sclerosis

Elevated CSF free kappa light chains (FKLCs) may predict disability in multiple sclerosis (MS). We reviewed records of 57 patients with MS with 15-year median follow-up for correlations of disability and CSF FKLCs. Levels > or = 1.53 microg/mL predicted progression to need for ambulatory assistan...

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Bibliographic Details
Published inNeurology Vol. 67; no. 7; p. 1288
Main Authors Rinker, 2nd, John R, Trinkaus, Kathryn, Cross, Anne H
Format Journal Article
LanguageEnglish
Published United States 10.10.2006
Subjects
Biomarkers - cerebrospinal fluid
Cohort Studies
Disability Evaluation
Female
Health Status Indicators
Humans
Immunoglobulin kappa-Chains - cerebrospinal fluid
Male
Multiple Sclerosis - cerebrospinal fluid
Multiple Sclerosis - diagnosis
Prognosis
Reproducibility of Results
Sensitivity and Specificity
Statistics as Topic
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Summary:Elevated CSF free kappa light chains (FKLCs) may predict disability in multiple sclerosis (MS). We reviewed records of 57 patients with MS with 15-year median follow-up for correlations of disability and CSF FKLCs. Levels > or = 1.53 microg/mL predicted progression to need for ambulatory assistance during follow-up (specificity 87.5%, positive predictive value 88.9%) or within 10 years (specificity 78.6%, positive predictive value 66.7%).
ISSN:1526-632X
DOI:10.1212/01.wnl.0000238107.31364.21