Real-Time Monitoring of Magnetic Nanoparticles Diffusion in Lateral Flow Microporous Membrane Using Spin Valve Sensors

This paper investigates real-time monitoring and detection of 10.5 nm magnetic nanoparticles (MNPs) (Fe 3 O 4 ) flowing in a nitrocellulose (NC) membrane over two spin valve sensors. The fabricated device gives information on the concentration of MNP flowing through the NC membrane of a typical late...

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Bibliographic Details
Published inIEEE transactions on magnetics Vol. 51; no. 1; pp. 1 - 4
Main Authors Chicharo, Alexandre, Cardoso, Filipe, Cardoso, Susana, Freitas, Paulo J. P.
Format Journal Article
LanguageEnglish
Published New York IEEE 01.01.2015
The Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subjects
Biomembranes
Magnetic resonance imaging
Magnetism
Nanoparticles
Spin valves
Strips
magnetic nanoparticles (MNPs)
spin valve (SV) sensors
Lateral flow
point-of-care
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Summary:This paper investigates real-time monitoring and detection of 10.5 nm magnetic nanoparticles (MNPs) (Fe 3 O 4 ) flowing in a nitrocellulose (NC) membrane over two spin valve sensors. The fabricated device gives information on the concentration of MNP flowing through the NC membrane of a typical lateral flow test, and gives relevant dynamic characteristics, such as flow rate and MNP distribution on capillary-driven systems. Sensor output varies linearly with MNP concentration. Experiments show average flow rates varying from 0.2 to 0.3 mm/s depending on MNP concentration. Signal shape [V(t)] gives information on MNP spatial distribution at the particle front flowing over the sensor.
ISSN:0018-9464
1941-0069
DOI:10.1109/TMAG.2014.2358645