Cellular cycling of substrate as a possible cryptic way for energy spilling in suspended cellular continuous cultures

Mass balances analysis of polyphasic dispersed systems showed that cellular cycling of the substrate involves (a) an increase in the specific metabolisation rate and (b) a decrease in the biomass yield coefficient (energy spilling). In biomass calculations, the substrate release rate can replace the...

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Bibliographic Details
Published inBiotechnology letters Vol. 22; no. 14; pp. 1143 - 1149
Main Author THIERIE, J
Format Journal Article
LanguageEnglish
Published Dordrecht Springer 01.07.2000
Springer Nature B.V
Subjects
Biological and medical sciences
Biomass
Biotechnology
Cell culture
Fundamental and applied biological sciences. Psychology
Methods. Procedures. Technologies
Microbial engineering. Fermentation and microbial culture technology
Microorganisms
Substrates
Continuous process
Substrate
Suspension culture
Maintenance energy
Microorganism culture
Recycling
Metabolism
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Summary:Mass balances analysis of polyphasic dispersed systems showed that cellular cycling of the substrate involves (a) an increase in the specific metabolisation rate and (b) a decrease in the biomass yield coefficient (energy spilling). In biomass calculations, the substrate release rate can replace the maintenance coefficient concept. Thus, decreasing the substrate transfer rates could improve cells or microorganisms strains of industrial importance.[PUBLICATION ABSTRACT]
ISSN:0141-5492
1573-6776
DOI:10.1023/A:1005616520482