Antibacterial and synergistic activity of a new 8-hydroxyquinoline derivative against methicillin-resistant Staphylococcus aureus

• Published in: Future microbiology Vol. 17; no. 6; pp. 425 - 436
• Main Authors: Joaquim, Angélica R, Boff, Roberta T, Adam, Franciele C, Lima-Morales, Daiana, Cesare, Maycon A, Kaminski, Taís Fa, Teixeira, Mário L, Fuentefria, Alexandre M, Andrade, Saulo F, Martins, Andreza F
• Format: Journal Article
• Language: English
• Published: England 01.04.2022
• Subjects: Anti-Bacterial Agents - pharmacology; Drug Synergism; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Oxyquinoline - pharmacology; antibacterial activity; synergistic activity; 8-hydroxyquinoline; MRSA
• ISSN: 1746-0913; 1746-0921
• DOI: 10.2217/fmb-2021-0198

To evaluate the antibacterial and synergistic effect of a new 8-hydroxyquinoline derivative (PH176) against MRSA. PH176 activity was determined by broth microdilution against 38 clinical isolates. The antibacterial and synergistic effects with oxacillin and nitroxoline were evaluated by time-kill assays to five MRSA isolates. Toxicity was evaluated by and models. The MIC and MIC of PH176 were 16 and 32 μg/ml, respectively. The PH176 and nitroxoline led to a reduction in colony count for four isolates and the combination of PH176 and oxacillin acted synergically for three isolates. Furthermore, PH176 was determined to be noncytotoxic/nonirritant. These results demonstrate that PH176 has revealed promising results to be a potential candidate to treat MRSA infections.