Thulium Laser for the Treatment of Posterior Urethral Valves in Infants

• Published in: Journal of endourology Vol. 37; no. 12; p. 1276
• Main Authors: Forlini, Valentina, Pellegrino, Chiara, Lena, Federica, Capitanucci, Maria Luisa, Van Uitert, Allon, Mosiello, Giovanni
• Format: Journal Article
• Language: English
• Published: United States 01.12.2023
• Subjects: Humans; Infant; Infant, Newborn; Lasers; Postoperative Hemorrhage; Retrospective Studies; Thulium - therapeutic use; Urethra - surgery; Urethral Obstruction - surgery; PUV; bladder outlet obstruction; endoscopy; thulium laser; posterior urethral valves
• ISSN: 1557-900X
• DOI: 10.1089/end.2023.0025

Thulium laser (ThL) has become popular in urology, because of its powerful action on tissue, achieving optimal ablation and hemostasis. Aim of our article was to evaluate efficacy of ThL in infants affected by posterior urethral valve (PUV) ablation. Clinical charts of 25 infants (age ≤12 months) who underwent PUV ablation were retrospectively reviewed. According to our protocol, all patients performed voiding cystourethrography and cystoscopy 6 to 8 months after initial treatment. Several factors, including age and weight at surgery, operative time, postoperative bleeding, catheterization period, postoperative urinary retention, retreatment for valve remnants, and stricture at follow-up, were evaluated. Preoperative, intraoperative, and postoperative data were analyzed. Mean age at primary surgery was 4.5 months (5 days-10.5 months) and mean weight at primary surgery was 5.7 kg (2.5-10.3 kg). Mean operative time was 29.5 minutes (range 15-50 minutes). None of the patients experienced intraoperative and postoperative bleeding. In all cases, postoperative catheterization period was 1 day. Residual valves were found in 6 of 25 (24%) patients. No cases of urethral stricture were registered during follow-up (48.4 months, range: 11-95). Analyzing literature data using other techniques, complication rate of ThL PUV ablation seems lower than standard treatments (electrofulguration, cold knife) and comparable with those reported with other laser techniques. PUV ablation with ThL has proven to be feasible and safe in infants. Further studies are needed to define the real effectiveness of this laser technology in PUV ablation. Miniaturized instruments and ThL technology make early PUV treatment feasible also in low body weight newborns.